学术成果
代表性论文：
1. Y. Yang, J. Huang, W. Wei, Q. Zeng, X. Li, D. Xing, B. Zhou*, T. Zhang*, Switching the NIR upconversion of nanoparticles for the orthogonal activation of photoacoustic imaging and phototherapy, Nature Communications, 2022, 13, 3149.
2. J. Zheng, Q. Zeng, R. Zhang, D. Xing*, T. Zhang*, Dynamic-reversible photoacoustic probe for continuous ratiometric sensing and imaging of redox status in vivo. J. Am. Chem. Soc. 2019, 141, 19226-29230.
3. L. Du, H. Qin, T. Ma, T. Zhang*, D. Xing*, In vivo imaging-guided photothermal/photoacoustic synergistic therapy with bioorthogonal metabolic glycoengineering-activated tumor targeting nanoparticles. ACS Nano, 2017, 11, 8930−8943.
4. T. Zhang, R. Lan, C.-F. Chan, G.-L. Law, W.-K. Wong*, K.-L. Wong*, In vivo selective cancer-tracking gadolinium eradicator as new-generation photodynamic therapy agent, PNAS, 2014, 111, E5492-E5497.
5. T. Zhang, X. Zhu, C. C. W. Cheng, W.-M. Kwok, H.-L. Tam, J. Hao, D. W. J. Kwong, W.-K. Wong*, K.-L. Wong*, Water-soluble mitochondria-specific ytterbium complex with impressive NIR emission. J. Am. Chem. Soc., 2011, 133, 20120.
研究论文列表：
33. Y. Yang, J. Huang, W. Wei, Q. Zeng, X. Li, D. Xing, B. Zhou*, T. Zhang*, Switching the NIR upconversion of nanoparticles for the orthogonal activation of photoacoustic imaging and phototherapy, Nature Communications, 2022, 13, 3149.
32. Q. Zeng, X. Li, S. Xie, D. Xing*, T. Zhang*, Specific disruption of glutathione-defense system with activatable single molecule-assembled nanoprodrug for boosted photodynamic/chemotherapy eradication of drug-resistant tumors, Biomaterials, 2022, 121867.
31. X. Li, Q. Zeng, R. Zhang, J. Li, D. Xing, T. Zhang*, Mitochondria-specific gadolinium (III) porphyrinate as efficient ROS generator for MRI visualization and sonodynamic-immunotherapy of deep localized tumors, Chemical Engineering Journal, 2022, 450, 138210.
30. M. Zhao, Q. Zeng, X. Li, D. Xing*, T. Zhang*, Aza-BODIPY-based phototheranostic nanoagent for tissue oxygen auto-adaptive photodynamic/photothermal complementary therapy, Nano Research, 2022, 15, 716–727.
29. R. Zhang, Q. Zeng, X. Li, D. Xing*, T. Zhang*, Versatile gadolinium(III)-phthalocyaninate photoagent for MR/PA imaging-guided parallel photocavitation and photodynamic oxidation at single-laser irradiation, Biomaterials, 2021, 275, 120993.
28. N. Wang, Q. Zeng, R. Zhang, D. Xing*, T. Zhang*, Eradication of solid tumors by chemodynamic theranostics with H2O2-catalyzed hydroxyl radical burst, Theranostics, 2021, 11, 2334-2348.
27. X. Jin#, Q. Zeng#, J. Zheng, D. Xing*, T. Zhang*, Aptamer-functionalized upconverting nanoformulations for light-switching cancer-specific recognition and in situ photodynamic–chemo sequential theranostics, ACS Appl. Mater. Interfaces, 2021, 13, 9316−9328.
26. Y. Yang, T. Zhang*, D. Xing*, Single 808 nm near-infrared-triggered multifunctional upconverting phototheranostic nanocomposite for imaging-guided high-efficiency treatment of tumors, J. Biophotonics, 2021, 14, e202100134.
25. J.-L. Wang, L. Zhang, M.-J. Zhao, T. Zhang,* Y. Liu, F.-L. Jiang*, Mitochondria-Targeted BODIPY Nanoparticles for Enhanced Photothermal and Photoacoustic Imaging In Vivo, ACS Appl. Bio Mater. 2021, 4, 1760−1770.
24. X. Li, Y. Zhao, J. Zheng, T. Zhang*, Boron dipyrromethene-based near-infrared fluorescent probe for the selective imaging and analyzing hydrogen peroxide in living cells, J. Lumin. 2021, 229, 117642.
23. J. Zheng, Q. Zhan, L. Jiang, D. Xing, T. Zhang*, K.-L. Wong*, A bioorthogonal time-resolved luminogenic probe for metabolic labelling and imaging of glycans. Inorg. Chem. Front., 2020,7, 4062-4069.
22. X. Li, Y. Zhao, T. Zhang*, D. Xing*, Mitochondria-specific agents for photodynamic cancer therapy: A key determinant to boost the efficacy, Adv. Healthcare Mater. 2020, 2001240.
21. R. Zhang, J. Zheng, T. Zhang*, In vivo selective imaging of metabolic glycosylation with a tetrazine-modified upconversion nanoprobe, RSC Advances, 2020, 10, 15990 – 15996.
20. Y. Wu, J. Zheng, Q. Zeng, T. Zhang*, D. Xing*, Light-responsive charge-reversal nanovector for high-efficiency in vivo CRISPR/Cas9 gene editing with controllable location and time. Nano Research, 2020, 13, 2399–2406.
19. Y. Wu, J. Zheng, D. Xing*, T. Zhang*, Near-infrared light controlled fluorogenic labeling of glycoengineered sialic acids in vivo with upconverting photoclick nanoprobe. Nanoscale, 2020, 10361-10368.
18. J. Zheng, Q. Zeng, R. Zhang, D. Xing*, T. Zhang*, Dynamic-reversible photoacoustic probe for continuous ratiometric sensing and imaging of redox status in vivo. J. Am. Chem. Soc. 2019, 141, 19226-29230.
17. J. Zheng, Y. Wu, D. Xing*, T. Zhang*, Synchronous detection of glutathione/hydrogen peroxide for monitoring redox status in vivo with a ratiometric upconverting nanoprobe. Nano Research, 2019, 12, 931-938.
16. Q. Zeng, R. Zhang, T. Zhang*, D. Xing*, H2O2-responsive biodegradable nanomedicine for cancer-selective dualmodal imaging guided precise photodynamic therapy, Biomaterials, 2019, 207, 39-48.
15. Y. Wu, G. Guo, J. Zheng, D. Xing*, T. Zhang*, Fluorogenic “photoclick” labeling and imaging of DNA with coumarin-fused tetrazole in vivo. ACS Sensors, 2019, 4, 44−51.
14. W. Fang, Y. Wei, Y. Ye, T. Zhang*, D. Xing*, Oxyhemoglobin-monitoring photodynamic theranostics with an 808 nmexcited upconversion optical nanoagent. Chemical Engineering J., 2018, 350, 108-119.
13. T. Ma, J. Zheng, T. Zhang*, D. Xing*, Ratiometric photoacoustic nanoprobes for monitoring and imaging of hydrogen sulfide in vivo. Nanoscale, 2018, 10, 13462-13470.
12. L. Du, H. Qin, T. Ma, T. Zhang*, D. Xing*, In vivo imaging-guided photothermal/photoacoustic synergistic therapy with bioorthogonal metabolic glycoengineering-activated tumor targeting nanoparticles. ACS Nano, 2017, 11, 8930−8943.
11. Q. Ding, Q. Zhan, X. Zhou, T. Zhang*, D. Xing*, Theranostic upconversion nanobeacons for tumor mRNA ratiometric fluorescence detection and imaging-monitored drug delivery. Small, 2016, 12, 5944.（Front Cover）
10. T. Zhang, R. Lan, L. Gong, B. Wu, Y. Wang, D. W. J. Kwong, W.-K. Wong, K.-L. Wong,* D. Xing*, An amphiphilic BODIPY-porphyrin conjugate: intense two-photon absorption and rapid cellular uptake for two-photon-induced imaging and photodynamic therapy, ChemBioChem, 2015, 16, 2357 – 2364. (Back Cover)
9. D. Qi, Q. Wang, H. Li, T. Zhang, R. Lan,* D. W. J. Kwong, W.-K. Wong, K.-L. Wong,* S. Li*, F. Lu*, SILAC-based quantitative proteomics identified lysosome as a fast response target to PDT agent Gd-N induced oxidative stress in human ovarian cancer IGROV1 cells, Mol. BioSyst., 2015, 11, 3059--3067
8. T. Zhang, R. Lan, C.-F. Chan, G.-L. Law, W.-K. Wong*, K.-L. Wong*, In vivo selective cancer-tracking gadolinium eradicator as new-generation photodynamic therapy agent, PNAS, 2014, 111, E5492-E5497.
7. T. Zhang, C.-F. Chan, R. Lan, W.-K. Wong, K.-L. Wong, Highly selective and responsive visible to near-IR ytterbium emissive probe for monitoring mercury(II), Chem. Eur. J. 2014, 20, 970 – 973
6. T. Zhang, C.-F. Chan, R. Lan, P.-S. Chan, N.-K. Mak, W.-K. Wong*, K.-L. Wong*, Selective differentiation of cancer cells by porphyrin-based ytterbium complexes targeting anionic phospholipid membrane. Chem. Commun., 2013, 49, 7252-7254.
5. T. Zhang, X. Zhu, W.-K. Wong*, H.-L. Tam, W.-Y. Wong*, Light-harvesting ytterbium (III)-porphyrinate-BODIPY conjugates: synthesis, excitation-Energy transfer, and two-photon-induced near-infrared-emission studies. Chem. Eur. J., 2013, 19, 739-748.
4. T. Zhang, C.-F. Chan, J. Hao, G.-L. Law, W.-K. Wong*, K.-L. Wong*, Fast uptake, water-soluble, mitochondria-specific erbium complex for a dual function molecular probe – imaging and photodynamic therapy. RSC Advances, 2013, 3, 382-385.
3. T. Zhang, X. Zhu, C. C. W. Cheng, W.-M. Kwok, H.-L. Tam, J. Hao, D. W. J. Kwong, W.-K. Wong*, K.-L. Wong*, Water-soluble mitochondria-specific ytterbium complex with impressive NIR emission. J. Am. Chem. Soc., 2011, 133, 20120.
2. H. Ke,* W. Li, T. Zhang, X. Zhu,* H.-L. Tam, A. Hou, D. W. J. Kwong*, W.-K. Wong*, Acetylene bridged porphyrin–monophthalocyaninato ytterbium(III) hybrids with strong two-photon absorption and high singlet oxygen quantum yield, Dalton Trans., 2012, 41, 4536–4543
1. X.-J. Zhu,* T. Zhang, S. Zhao, W.-K. Wong,* W.-Y. Wong, Synthesis, Structure, and Photophysical Properties of Some Gadolinium(III) Porphyrinate Complexes, Eur. J. Inorg. Chem. 2011, 3314–3320
