Xuegeng Wang
Associate professor 生命科学学院
Field: Epigenetics in fish, Gene-environment interactions, Developmental toxicology, Aquaculture breeding
wangxuegeng@scnu.edu.cn

Education

Ph.D.,  Peking University,  2017
B.S.,  Nankai University,  2010

 

Experience

Associate Professor, 12/2022 - Current. School of Life Sciences, South China Normal University
Senior Research Fellow, 12/2020 – 11/2022. School of Life Sciences, South China Normal University
Postdoctoral Fellow, 05/2017 - 11/2020. The University of North Carolina at Greensboro


 

Teaching

Developmental Biology,
Epigenetics, 
Evo-Devo,
Cell engineering,

Genetic Breeding in Aquaculture

Academics

Honor

* Co-first author; # Corresponding author
2026-present:
[37].  Qingping Chen, Xiang Li, Duan Pi, Ramji Kumar Bhandari, Xuegeng Wang#, Occurrence and toxicological effects of the bisphenol F in aquatic environments, Aquatic Toxicology. 2026; 299: 107972,
[36].  Minxing Liang, Zitian Xu, Leyi Long, Peitong Wang, Qingping Chen, Guobin Shi, Fang Liang, Jun Zhao, Kangsen Mai, Yutao Miao#, Xuegeng Wang#, Enhanced muscle growth via DNA methylation editing of mstnb exon in zebrafish, Aquaculture and Fisheries. 2026; 11(5): 893-899
[35].  Fang Liang*, Xue Wang*, Weiwei Cai, Puyu Huang, Huiling Li, Donghua Xiong, Danxia Yang, Jiaying Gan, Jingbin Yu, Jiangmei Gao, Chao Li, Xuegeng Wang#, Wei Qin#, RPL34 deficiency establishes a Δ113p53-tunable model of DBA and enables in vivo reclassification of a missense variant, Genes & Diseases. 2026; 102223
[34].  Fang Liang*, Biyu Wu*, Jiayi Liu, Xue Wang, Minxing Liang, Chaoyi Wang, Jingyi Zhang, Junjie Wang, Yutao Miao, Kangsen Mai, Jun Zhao#, Xuegeng Wang#. Inheritance of the epigenetic signature and reduced intermuscular bone phenotype acquired via DNA methylation editing of the runx2b promoter in zebrafish. Zoological Research. 2026.
[33].  Junxian Zhu,Yingqi Ning,Caixia Gao,Chen Chen, Liqin Ji, Xiaoyou Hong, Xiaoli Liu, Chengqing Wei, Xinping Zhu, Xuegeng Wang#, Wei Li#. Role of Col1a2 in Collagen Deposition in the Carapace of the Chinese Soft-Shelled Turtle (Pelodiscus sinensis): From Molecular Evolution to Expression Profile and Then to Function Validation. International Journal of Molecular Sciences. 2026; 27, 2160.
[32].  Duan Pi*, Xiang Li*, Zitian Xu, Peitong Wang, Zhiying Liang, Bingying Li, Yafen Guo, Yongsi Huang, Xiaohong Song, Junjie Wang#, Xuegeng Wang#, Comparative study on the acute and developmental toxicity of bisphenol S and F in medaka (Oryzias latipes), Environmental Toxicology and Chemistry. 2026; 45(3):632-643.
2025:
[31].  Jiaxiang Che, Zhong Li, Xuegeng Wang, Meisha Guo, Haiqin Wang, Liangliang Huang, Honghu Zeng, Xiaohong Song. Integrated transcriptomics, metabolomics, and histopathology reveal molecular mechanisms of sublethal triclosan exposure in mosquitofish larvae (Gambusia affinis). Aquatic Toxicology, 2025; 286: 107471
[30].  Sourav Chakraborty, Seraiah T. Coe, Santosh Anand, Mehwish Faheem, Xuegeng Wang, Ramji Kumar Bhandari. PFOS caused fertility defects and disrupted spermatogenic gene networks in medaka with a transgenerational history of ancestral BPA exposure. Environmental Research. 2025; 282: 122056
[29].  Weiwei Cai, Jiaying Gan, Jingbin Yu, Huiling Li, Jiahui Wu, Xue Wang, Donghua Xiong, Xuegeng Wang, Fang Liang. Research progress on experimental models of Diamond-Blackfan anemia. Acta Laboratorium Animalis Scientia Sinica. 2025. (Review in Chinese)
[28].  Doldron, Megan S., Sourav Chakraborty, Santosh Anand, Mehwish Faheem, Beh Reh, Xuegeng Wang, Saurav Mallik, Zhenquan Jia, Ramji Kumar Bhandari. Cellular and Transcriptional Responses of Human Bronchial Epithelial Cells to Delta-9-Tetrahydrocannabinol In Vitro. International Journal of Molecular Sciences. 2025; 26(11), 5212
[27].  Yuwen Liu, Chao Li, Yiren Qiu, Sihong Chen, Yijun Luo, Donghua Xiong, Jun Zhao, Jianmin Ye, Xuegeng Wang, Wei Qin, Fang Liang. Base editors in zebrafish: a new era for functional genomics and disease modeling. Frontiers in Genome Editing. 2025; 7:1598887.
[26].  Xuegeng Wang*, Biyu Wu*, Qianhui Chen, Fang Liang, Junjie Wang, Chao Li, Liyun Ding, Kangsen Mai, Jun Zhao. Research progress and prospects on the genetic characteristics and breeding of Pengze crucian carp[J]. Journal of fisheries of China, 2025; 49(3): 039101. (Review in Chinese)
[25].  Biyu Wu, Zirui Cheng, Xiang Li, Minxing Liang, Xue Wang, Duan Pi, Jiayi Liu, Huiling Li, Jun Zhao, Junjie Wang, Fang Liang#, Xuegeng Wang#. The developmental toxicity of bisphenol F exposure on the zebrafish larvae. Ecotoxicology and Environmental Safety. 2025; 298:118282
2024:
[24].  Xuegeng Wang#, Ramji Kumar Bhandari, Kangsen Mai. Epigenome editing: A new approach to aquaculture breeding. Reviews in Aquaculture. 2024; 16(4): 1463-1466.
[23].  Xuegeng Wang, Ramji K Bhandari. Methylome profile of medaka eggs and sperm. Epigenetics. 2024; 19(1): 2417151
[22].  Bingying Li*, Yongsi Huang*, Duan Pi, Xiang Li, Yafen Guo, Zhiying Liang, Xiaohong Song, Junjie Wang#, Xuegeng Wang#. Effects of Acute and Developmental Exposure to Bisphenol S on Chinese Medaka (Oryzias sinensis). Journal of Xenobiotics. 2024; 14(2):452-466.
2023:
[21].  Deborah Killian, Mehwish Faheem, Beh Reh, Xuegeng Wang, Ramji Kumar Bhandari. Effects of Chronic Roundup Exposure on Medaka Larvae. Journal of Xenobiotics. 2023; 13(3): 500-508
[20].  Zhiying Liang, Yafen Guo, Duan Pi, Xiang Li, Bingying Li, Yongsi Huang, Xiaohong Song, Ramji Kumar Bhandari, Xuegeng Wang#. Transcriptome Analysis of the Developmental Effects of Bisphenol F Exposure in Chinese Medaka (Oryzias sinensis). International Journal of Molecular Sciences. 2023; 24(13):10898
[19].  Marlee Vassall, Sourav Chakraborty, Yashi Feng, Mehwish Faheem, Xuegeng Wang, Ramji Kumar Bhandari. Transcriptional Alterations Induced by Delta-9 Tetrahydrocannabinol in the Brain and Gonads of Adult Medaka. Journal of Xenobiotics. 2023; 13(2): 237-251
[18].  Fang Liang, Zijiong Dong, Jianmin Ye, Wei Hu, Ramji Kumar Bhandari, Kangsen Mai, Xuegeng Wang#. In vivo DNA methylation editing in zebrafish. Epigenetics. 2023; 18(1): 2192326
[17].  Xuegeng Wang, Jie Yu, Yutao Miao, Kangsen Mai, Lei Wang. Research progress and prospect of marble goby (Oxyeleotris marmorata). Journal of Fisheries of China. 2023. (Review in Chinese)
[16].  Sourav Chakraborty, Manthi Dissanayake, Julia Godwin, Xuegeng Wang, Ramji K Bhandari. Ancestral BPA exposure caused defects in the liver of medaka for four generations. Science of The Total Environment. 2023; 856: 159067
2022:
[15].  Beh Reh, Xuegeng Wang#, Yashi Feng, Ramji K Bhandari#. Potassium perchlorate effects on primordial germ cells of developing medaka larvae. Aquatic Toxicology. 2022; 251:106283.
[14].  Ayalew Ligaba-Osena, Mohammad Salehin, Muhammad Numan, Xuegeng Wang, Sang-Chul Choi, Dereje Jima, Louis-Mari Bobay, Wanli Guo. Genome-wide transcriptome analysis of the orphan crop tef (Eragrostis tef (Zucc.) Trotter) under long-term low calcium stress. Scientific Reports. 2022; 12, 19552.
[13].  Muhammad Numan, Wanli Guo, Sang-Chul Choi, Xuegeng Wang, Boxuan Du, Weibo Jin, Ramji Kumar Bhandari, Ayalew Ligaba-Osena. Analysis of miRNAs responsive to long-term calcium deficiency in tef (Eragrostis tef (Zucc.) Trotter). Plant Direct. 2022; 6(5), e400.
2021:
[12].  Xuegeng Wang, Jue Zhao, Zuoyan Zhu. Exogenous expression of pou5f3 facilitates the development of somatic cell nuclear transfer embryos in zebrafish at the early stage. Cellular Reprogramming. 2021; 23(3): 191-197.
[11].  Xiaohong Song, Xuegeng Wang, Xin Li, Xiaoyu Yan, Yanpeng Liang, Yuequn Huang, Liangliang Huang, Honghu Zeng. Histopathology and transcriptome reveals the tissue-specific hepatotoxicity and gills injury in mosquitofish (Gambusia affinis) induced by sublethal concentration of triclosan. Ecotoxicology and Environmental Safety. 2021; 220: 112325.
2020:
[10].  Albert J. Thayil*, Xuegeng Wang*, Pooja Bhandari, Frederick S. vom Saal, Donald E. Tillitt, Ramji K. Bhandari. Bisphenol A and 17α-ethinylestradiol-induced transgenerational gene expression differences in the brain-pituitary-testis axis of medaka, Oryzias latipes. Biology of Reproduction. 2020; 103(6): 1324-1335.
[9].    Xuegeng Wang*, Xiaohong Song*, Ramji K. Bhandari. Distinct expression patterns of seven microRNAs during early embryonic development in medaka (Oryzias latipes). Gene Expression Patterns. 2020; 37:119133.
[8].    Xiaohong Song*, Xuegeng Wang*, Ramji K. Bhandari. Developmental and epigenetic defects in medaka (Oryzias latipes) embryo induced by triclosan exposure. Chemosphere. 2020; 261:127613.
[7].    Ramji K. Bhandari*, Xuegeng Wang*, Caitlin M. Jandegian, Frederick S. vom Saal, Donald E. Tillitt. Transcriptome analysis of testis reveals the effects of developmental exposure to bisphenol A or 17α-ethinylestradiol in medaka (Oryzias latipes). Aquatic Toxicology. 2020; 225:105553.
[6].    Xuegeng Wang, Ramji K. Bhandari. DNA methylation reprogramming in medaka fish- a promising animal model for environmental epigenetics research. Environmental Epigenetics. 2020; 6(1): dvaa008.
[5].    Xuegeng Wang, Ramji K. Bhandari. The dynamics of DNA methylation during epigenetic reprogramming of primordial germ cells in medaka (Oryzias Latipes). Epigenetics. 2020; 15 (5): 483-498.
2019:
[4].    Xuegeng Wang, Ramji K. Bhandari. DNA methylation dynamics during epigenetic reprogramming of medaka embryo. Epigenetics. 2019; 14 (6): 611-622.
[3].    Xuegeng Wang, Diamond Hill, Donald E. Tillitt, Ramji K. Bhandari. Bisphenol A and 17alpha-ethinylestradiol induced transgenerational differences in expression of osmoregulatory genes in the gill of medaka (Oryzias latipes). Aquatic Toxicology. 2019; 211: 227-234.
2013:
[2].    Lan Jiang, Jing Zhang, Jing-Jing Wang, Lu Wang, Li Zhang, Guoqiang Li, Xiaodan Yang, Xin Ma, Xin Sun, Jun Cai, Jun Zhang, Xingxu Huang, Miao Yu, Xuegeng Wang, Feng Liu, Chung-I Wu, Chuan He, Bo Zhang, Weimin Ci, Jiang Liu. Sperm, but Not Oocyte, DNA methylome is inherited by zebrafish early embryos. 2013; Cell, 153:773-784.
[1].    Xuegeng Wang, Zuoyan Zhu, Yonghua Sun, Jue Zhao. Nuclear transfer and reprogramming in fish. Hereditas (Beijing), 2013; 35(4): 433-440. (Review, in Chinese)
 

Affiliations

Young editorial board member:
·Science in One Health                   2023-present
·Genomics Communications           2024-present
·Chinese Journal of Fisheries         2025-present
·South China Fisheries Science        2025-present
·Journal of South China Agricultural University          2023-2025
 

Students

CN